You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.
However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.
Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.
Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.
Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.
Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:
Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.
Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.
Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.
The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.
In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.
Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.
So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.
However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.
Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.
Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.
Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.
We’d generally recommend trying Second Nature’s before considering a weight-loss jab.
Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.
At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.
In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.
Second Nature was more than twice as effective at supporting weight loss than the other four providers.
However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.
Second Nature has been in medicine for less than five years. You can use our proven track record to help you get the help you need.Sold and Supplied by Healthylife Pharmacy
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Xenical Orlistat (120mg) 84 Capsules is a prescription only medicine prescribed by a doctor to treat obesity.
Dietary fats are large molecules that need to be broken down before they can be absorbed into the body. They are broken down by enzymes called lipases. That is, lipases play an important role in the digestion of dietary fat. When taken with a meal, Xenical interferes with the activity of these enzymes. This allows about 30% of the fat eaten in the meal to pass through the gut undigested. Therefore, your body cannot store these excess calories as fatty tissue or use them as a source of energy. This helps you to reduce your weight by burning up fat that you are already carrying, maintain your lower weight and minimise any weight regain. Losing even small amounts of weight and keeping it off produces additional health benefits for you, especially when you are at risk for other diseases such as heart disease and diabetes. Xenical can also help to improve risk factors, such as high blood pressure, high cholesterol and high blood sugar. If these are not treated, they could lead to other diseases such as hypertension and diabetes. Xenical should be taken in conjunction with a well-balanced calorie-controlled diet and other appropriate measures such as exercise.Active Ingredients:Xenical does not contain sucrose, gluten, tartrazine or any other azo dyes. Active ingredient - orlistat each Xenical capsule contains 120 mg orlistatInactive ingredients
DirectionsTake 1 capsule with each of the 3 main meals per day. It can be taken during the meal or up to 1 hour after the meal is consumed.Warnings & Disclaimers
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Add this link to your accountAdd this link to your account Order link links Rossi G, Kibic M, Riedl S, Wolk A, et al. "Xenical for weight loss in obese and overweight patients with type 2 diabetes mellitus."Arthritis. 1998; 14: 789-79.
Xenical for Weight Loss in Obesity. 2022; 11(6): 689-794.
Cerner Multocumented. "Xenical in weight loss in obese patients."2022;21(6):914.
Rossi G, Kibic M, Riedl S, et al. "Xenical for obesity and the prevention of cardiovascular events.How does the drug interact with Xenical Capsule:Co-administration of teriflunomide and Xenical Capsule can increase the risk of developing liver problems.How to manage the interaction:Co-administration of Teriflunomide and Xenical Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like itching, dark urine, rigid muscles, irregular heartbeat, and confusion symptoms, consult your doctor before taking the medication. Patients who are taking teriflunomide or other substrates of the liver enzymes should avoid taking the medication. This precaution is only recommended for patients with severe liver disease. Further details can be found in the product information leaflet.
Co-administration of nelfinavir and Xenical Capsule can increase the risk of liver problems.Co-administration of nelfinavir and Xenical Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like itching, dark urine, rigid muscles, irregular heartbeat, and abdominal perforation, consult your doctor before using the medication. Individual reactions to nelfinavir and Xenical Capsule can vary and reaction times can be slightly slower than those seen with teriflunomide and terbutaline. While taking nelfinavir or any liver enzymes supplements, advises against using other medications that can increase the risk of cardiovascular side effects.Co-administration of carbendimine and Xenical Capsule can increase the levels of nelfinavir and Xenical Capsule in the body.Although not recommended, if you experience nausea, fatigue, loss of appetite, or swelling or pain in the chest or arm, inform your doctor immediately. Avoid using the medication if you have a history of liver disease, myasthenia gravis, peptic ulcers, anuria, or unexplained frequency. Patients with diabetes who are taking this medication should also be aware of its effects on the body.Co-administration of sulphate and Xenical Capsule can increase the levels of nelfinavir in the body.Although not recommended, if you experience nausea, fatigue, loss of appetite, or swelling and tenderness in the arms or legs, inform your doctor immediately. Patients with kidney disease or those taking digoxin should also be aware of its effects on the body.Co-administration of sirolimus and Xenical Capsule can increase the levels of teriflunomide and Xenical Capsule in the body.Although not recommended, if you experience nausea, fatigue, loss of hunger, swelling and tenderness in the arms or legs, and feeling tired is milder side effects of sirolimus may be experienced.Co-administration of Teriflunomide and Xenical Capsule can increase the levels of teriflunomide and Xenical Capsule in the body.Although not recommended, if you experience nausea, fatigue, loss of hunger, swelling and tenderness in the arms or legs, and feeling tired is milder side effects of teriflunomide and Xenical Capsule can be experienced. Patients with kidney disease and those taking digoxin should also be aware of its effects on the body.
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